Serological Tests

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چکیده

Serological diagnosis of an acute infection can be done by the demonstration of seroconversion and/or agent-specific IgM antibodies in the serum samples. Seroconversion describes 4 fold or more increase in antibody levels of the serum samples which is collected at the acute and convelescent phase (10-15 days intervals) of an infection. As the detection of seroconversion is time-consuming, the agent-specific IgM antibodies –an indicative marker for the acute infectioncan easily be detected in a single serum sample, by rapid immunologic methods. However, as the IgM antibodies may be persistant even after the acute infection in some cases, or may reappear in reinfections and/or re-activations, it should be kept in mind that the presence of agentspecific IgM is not a strict marker of the primary acute infection. The detection of IgA antibodies is also useful for the serologic diagnosis of mucosal infections.

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تاریخ انتشار 2013